Faithin Omaha eBook Collection

Download or read book Transporters in Drug Development written by Yuichi Sugiyama and published by Springer Science & Business Media. This book was released on 2013-09-16 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transporters in Drug Development examines how membrane transporters can be dealt with in academic–industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters’ impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.