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Download or read book The Identification and Characterization of Novel Basic Helix-loop-helix Proteins in Caenorhabditis Elegans written by Tracee Lynn McMiller and published by . This book was released on 2004 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic helix-loop-helix (bHLH) transcription factors regulate the expression of genes required for various aspects of normal development in eukaryotes. bHLH proteins contain a DNA-binding domain that is highly conserved among proteins from different organisms, yet possessing similar structure and function. A database search of the Caenorhabditis elegans genome identified forty-six C. elegans genes each containing a putative bHLH domain, many with significant homology to other bHLH genes with confirmed functions in development. This thesis largely covers previously undescribed C. elegans genes with bHLH domains that are significantly homologous to members of the Achaete-Scute, Hairy-related/Enhancer of Split, and Atonal-related subfamilies that primarily regulate neurogenesis [C17C3.8 (hlh-26) and F31A3.4 (hlh-29)], and one bHLH gene [F38C2.2 (hlh-17)] whose transcript is significantly homologous to Beta3, a regulator of insulin expression. -- Abstract.