Protein Crystallography in Drug Discovery, Volume 20

Protein Crystallography in Drug Discovery, Volume 20
Author :
Publisher : John Wiley & Sons
Total Pages : 284
Release :
ISBN-10 : 3527306781
ISBN-13 : 9783527306787
Rating : 4/5 (787 Downloads)

Book Synopsis Protein Crystallography in Drug Discovery, Volume 20 by : Robert E. Babine

Download or read book Protein Crystallography in Drug Discovery, Volume 20 written by Robert E. Babine and published by John Wiley & Sons. This book was released on 2004-02-13 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method. Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive high-resolution structures for such important target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments, such as for high-throughput crystallography and microcrystallization, is also included. A valuable companion for crystallographers involved in protein structure determination as well as drug developers pursuing the structure-based approach for use in their daily work.


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