Phosphoinositide 3-kinase in Health and Disease
Author | : Christian Rommel |
Publisher | : Springer Science & Business Media |
Total Pages | : 311 |
Release | : 2010-10-17 |
ISBN-10 | : 9783642136634 |
ISBN-13 | : 364213663X |
Rating | : 4/5 (63X Downloads) |
Download or read book Phosphoinositide 3-kinase in Health and Disease written by Christian Rommel and published by Springer Science & Business Media. This book was released on 2010-10-17 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here we give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here