Multiple Testing Procedures with Applications to Genomics

Multiple Testing Procedures with Applications to Genomics
Author :
Publisher : Springer
Total Pages : 0
Release :
ISBN-10 : 1441923799
ISBN-13 : 9781441923790
Rating : 4/5 (790 Downloads)

Book Synopsis Multiple Testing Procedures with Applications to Genomics by : Sandrine Dudoit

Download or read book Multiple Testing Procedures with Applications to Genomics written by Sandrine Dudoit and published by Springer. This book was released on 2010-11-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.


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