Faithin Omaha eBook Collection

Download or read book Brain Insulin Resistance in Neurodevelopmental and Neurodegenerative Disorders: Mind the Gap! written by Eugenio Barone and published by Frontiers Media SA. This book was released on 2021-10-04 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: The failure of insulin signaling – a condition known as insulin resistance – is a key pathological feature of both type 2 diabetes (T2DM, systemic insulin resistance) and Alzheimer’s disease and related dementias (ADRDs, brain insulin resistance) and greatly contribute to their development. Considerable overlap has been identified in the risk factors, comorbidities and putative pathophysiological mechanisms of ADRDs and T2DM, thus proposing AD as type 3 diabetes.