Faithin Omaha eBook Collection

Download or read book A Structure-function Analysis of the CGMP-dependent Protein Kinase written by Brent William Osborne and published by . This book was released on 2011 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This structural work described herein highlights the critical importance of dimer communication in PKG biology and will likely serve as an improved platform for the strategic development of therapeutic agents aimed at treatment and prevention of cGMP-dependent pathologies. Currently, the use of non-cyclic nucleotide modulators of PKG activity is in its infancy. Here, we also performed the first biochemical analysis of two lead compounds, which exhibit the potential to directly target PKG for pharmacological intervention.