Faithin Omaha eBook Collection

Download or read book The Role of the Integrase C-terminus in Replication and Targeted Integration of the Yeast Retrotransposon Ty5 written by Troy Leon Brady and published by . This book was released on 2007 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mobile genetic elements have the inherent potential to shape the genomes of their hosts. The retroelements, which include the retrotransposons and retroviruses, are a particularly abundant class of mobile elements. The site of retroelement insertion in the host genome is largely determined by the element-encoded protein integrase (IN). Research presented here addresses three aspects of IN from the retrotransposon Ty5: the function of a conserved domain (GKGY) in the IN C-terminus, the role of IN post-translational modification in targeted integration, and the origin of the Ty5 targeting mechanism.