Molecular Toxicology Protocols

Molecular Toxicology Protocols
Author :
Publisher : Springer Science & Business Media
Total Pages : 478
Release :
ISBN-10 : 9781592598403
ISBN-13 : 1592598404
Rating : 4/5 (404 Downloads)

Book Synopsis Molecular Toxicology Protocols by : Phouthone Keohavong

Download or read book Molecular Toxicology Protocols written by Phouthone Keohavong and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of cutting-edge techniques for analyzing genotoxic exposure and detecting the resulting biological effects-including endogenous metabolites-up to and including the development of cancer. The authors emphasize analytical methods that can be specifically applied to human populations and patients. Among the applications detailed are the analysis of interactions between such cellular macromolecules as DNA and proteins and chemical and physical agents, the assessment of medically relevant toxicity, and the characterization of genetic alterations induced in transgenic animals by in vivo systems. There are also methods for the analysis of genotoxic exposure during gene expression, of cytotoxicity caused by the induction of apoptosis, of genetic alterations in reporter genes and oncogenes, early (premalignant) detection of altered oncogenes, and of individual variation in biotransformation and DNA repair capacity.


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