Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy
Author | : Emmanuel Donnadieu |
Publisher | : |
Total Pages | : |
Release | : 2016 |
ISBN-10 | : 3319422227 |
ISBN-13 | : 9783319422220 |
Rating | : 4/5 (220 Downloads) |
Download or read book Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy written by Emmanuel Donnadieu and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy. The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.