Faithin Omaha eBook Collection

Download or read book Approaches to Advance Cancer Vaccines to Clinical Utility written by An M. T. Van Nuffel and published by Frontiers Media SA. This book was released on 2019-12-27 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although cancer vaccines have yielded promising results both in vitro and in animal models, their translation into clinical application has not been very successful so far. Through the success of immune checkpoint inhibitors, the tumor immunotherapy field revived and led to important new insights. A better understanding of the functional capacity of different dendritic cell (DC) subsets and the immunogenicity of tumor antigens, more particularly of neoantigens, have important implications for the improvement of cancer vaccines. These insights can guide the development of novel strategies, to enhance the clinical utility of cancer vaccines. The aim of this Research Topic is therefore to provide a comprehensive overview of current issues regarding cancer vaccine development with an emphasis on novel approaches toward enhancing their efficacy.